How do you deal with a fallout of heavenly proportions? with the angelic Host's descent to Earth, Sam and Dean are now facing a world inhabited by thousands of powerful beings, who soon form their own chaotic agendas. Before tackling the threat of the 'loose nukes' roaming the globe, however, the Winchester's engage in their most personal conflict yet. Meanwhile, Castiel finds he's more vulnerable and yet capable of more humanity; than ever. As the threat escalates, a way must be found to reopen the gates of Heaven and head off a demon insurrection in Hell.