Last season, the Charmed Ones (Melonie Diaz, Madeleine Mantock, Sarah Jeffery) and their Whitelighter Harry (Rupert Evans) battled the Faction - a cabal of humans trying to steal magic for themselves, led by billionaire Julian Shea (guest star Eric Balfour). In this new season, Mel, Macy and Maggie will be forced to try and save the magical world from extinction and navigate a mysterious magical allergy that's keeping them apart, all while attempting to reestablish themselves in the real world... as a scientist, a student and a teacher.