Veronica (Emmanuelle Chriqui, You Don't Mess with the Zohan) and Roxie (Emily Osment, Hannah Montana: The Movie) are two gorgeous young women - who happen to be a team of expertly trained and highly lethal contract killers. While out on an errand for their boss, Mother (Gina Gershon, Face/Off), they find an unpleasant surprise in the trunk of their car that turns these hunters into the hunted. With the tables turned, the girls must go on the run from a sadistic millionaire, an FBI agent (David Arquette, Scream) and Mother's own deadly squad of assassins (led by Clifton Collins Jr., Pacific Rim).