Confined to an asylum for the criminally insane for the past four years, Nica (Fiona Dourif) is wrongly convinced that she, not Chucky, murdered her entire family. But when her psychiatrist introduces a new group therapy tool - a "Good Guy" doll - a string of grisly deaths plague the asylum and Nica starts to wonder if maybe she isn't crazy after all. Andy (Alex Vincent), Chucky's now-grown-up nemesis from the original Child's Play, races to Nica's aid. But to save her he'll have to get past Tiffany (Oscar-nominee Jennifer Tilly), Chucky's long-ago bride, who will do anything, no matter how deadly or depraved, to help her beloved devil doll.