In an anonymous motel room on the U.S./Mexico border, a Ciudad Juárez hitman speaks. He has killed hundreds of people and is an expert in torture and kidnapping. He was simultaneously on the payroll of the Mexican drug cartels and a commander of the Chihuahua State Police. There is currently a $250,000 contract on his life and he lives as a fugitive, though he has never been charged with a crime in any country. With his face obscured by a black mesh hood, he tells his story to the camera inside the very motel room he once used to hold and torture kidnapped victims. Aided only by a magic marker and notepad, which he uses to illustrate and diagram his words, the sicario describes, in astounding detail, his life of crime, murder, abduction and torture.