Years after the events of The Real Ghostbusters, the original Ghostbusters crew have all moved on to different careers - except for Egon Spengler. After a prolonged quiet period, Egon is now a college professor on the paranormal and the sole caretaker of the firehouse - and Slimer. When supernatural activity suddenly resurges across New York and once again threatens the city, he recruits the help of four college students to form an all-new Ghostbusters team.