At the ripe age of 19, Ed Green (Pras) is a dismal failure. He has resigned himself to smoking and selling Marijuana for the psychotic local drug dealer Sadico, until Sadico's sister pins her pregnancy on Ed and Sadico vows to kill Ed. Hearing of this, Ed decides to skip town, unsure of where to go and hide. As a last act of desperation, Ed decides to enroll at a local University and hide out by taking classes and living on Campus. Unfortunately, Ed is assigned dorm room 420, with roommate "Bud" Carter (Aries Spears). Bud quickly becomes a negative influence on Ed, who falls back into his old ways. But the Mexican Gang has picked up on Ed's trail, sending goons to register as students on the same Campus to find Ed. Ed is meanwhile developing a romantic relationship with fellow student Lisa (Leila Arcieri) but must lure her away from her Big Man on Campus boyfriend Craig (Hill Harper). The plot thickens when police detectives set up a sting operation to address the growing problem of drugs on campus.