Edie Falco stars as title character Jackie Peyton, a drug-addicted emergency room nurse in a New York City hospital. For Jackie, every day is a high-wire act of juggling patients, doctors, fellow nurses and her own indiscretions. The second season of the Showtime Original Series NURSE JACKIE continues it's look deep inside the complicated heart and soul of a functioning addict, a loving wife and mother, and a first-class nurse. Starring Edie Falco, Eve Best, Peter Facinelli.