Separated in the chaos when their city was bombed, students Shuji and Chise's lives are shattered despite the actions of a mysterious defender. After reuniting with Chise in the ruins, Shuji is horrified to discover that she is no longer the girl he knew. Twisted and reshaped by nightmarish science, her body has been transformed into something that isn't completely human: a living weapon! And even worse, the remaining facets of the person she once was seem to be fading away. Can Shuji continue to feel love for the shell of the person Chise once was? And how long can Chise's soul endure inside a device whose only purpose is to kill? As the fires of war burn, a young woman teeters on the brink of becoming the engine of the final apocalypse in SHE, THE ULTIMATE WEAPON!