It strikes without warning. It can morph through walls, ceilings, floors. There is no place to hide. Behind every corner lies a potential doorway to death. After fifty years the Shrieker has been summoned again. Five will die tonight. The sixth will become it's master. When you hear the sound of it's voice... your time has come. Clark (Tanya Dempsey), a young Mathematics major at a University, thinks she's found the best deal for student housing: a group of squatters who live in an abandoned hospital secretly. The quirky residents let her into their community provided she follow the rules, including not telling anyone about her living arrangements. All seems wonderful, until she discovers that the reason that the hospital was abandoned was a series of murders in the 1940s by a strange "shrieking killer" who was never captured - and the discovery that someone who's living in the hospital is using occult means to bring back the demonic "Shrieker".