In the show's eleventh season, Sam and Dean Winchester (Jared Padalecki & Jensen Ackles) faced their greatest challenge yet: the all-powerful Darkness, better known as the sister of God. Freed from her prison by Dean, she threatened all of creation, until God (with the help of Sam, Dean, Castiel and Crowley), made amends with her. Before they left Earth, however, they restored Sam & Dean's mother, Mary Winchester, to life. In Season Twelve, the Winchesters must not only contend with an escaped Lucifer and the British Men of Letters (who've come to end their hunting days), but they'll also have to relearn what it is to be a family again after all these years.